Soiled it

A cartoon wolf in a Vault Boy jumpsuit gives a thumbs-up against a radial background, then the scene shifts to a group of anthropomorphic horses in a post-apocalyptic setting with a "Fallout Equestria" sign, followed by a single pony holding a glowing green weapon, and finally a large robot with a small pony on its shoulder shouting "Friendship is non-negotiable!", while the bottom half of each frame consistently shows a yellow sponge character with a wide-open mouth in a state of shock or distress, bound by ropes in an underwater environment.